Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease

Ture-Ozdemir, Filiz; Tulunay, Aysin; Elbasi, Mehmet; Tatli, Imren; Maurer, Anne-Marie; MUMCU, GONCA; Direskeneli, RAFİ; Eksioglu-Demiralp, Emel

doi:10.1093/rheumatology/kes399

Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease

Ture-Ozdemir F., Tulunay A., Elbasi M. O., Tatli I., Maurer A., MUMCU G., ...Daha Fazla

RHEUMATOLOGY, cilt.52, sa.5, ss.800-805, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 52 Sayı: 5
Basım Tarihi: 2013
Doi Numarası: 10.1093/rheumatology/kes399
Dergi Adı: RHEUMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.800-805
Anahtar Kelimeler: Behcet's disease, dendritic cells, inflammasome, neutrophils, pattern recognition receptors, INFECTIOUS ETIOLOGY, INNATE IMMUNITY, MANIFESTATIONS, PATHOGENESIS, ASSOCIATION, EXPRESSION, NOD2
Marmara Üniversitesi Adresli: Evet

Özet

Objective. Activated innate immunity is implicated in the pathogenesis of Behcet's disease (BD). To clarify the mechanisms of innate immune responses, we investigated inflammasome activation in dendritic cells (DCs) and neutrophils, following stimulation with two different pattern recognition receptors (PRRs) RIG-1-like (RLR) and NOD-like (NLR) in patients with BD.