The effect of phosphodiesterase-5 inhibition by sildenafil citrate on inflammation and apoptosis in rat experimental colitis

Karakoyun B., Uslu Ü., Ercan F., Aydın M. Z., Yüksel M., Velioğlu Öğünç A., ...More

LIFE SCIENCES, vol.89, pp.402-407, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 89
  • Publication Date: 2011
  • Doi Number: 10.1016/j.lfs.2011.07.005
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.402-407
  • Keywords: Nitric oxide, Phosphodiesterase, Sildenafil citrate, Trinitrobenzenesulphonic acid, TRINITROBENZENE SULFONIC-ACID, BOWEL-DISEASE, REACTIVE OXYGEN, MODEL, COLON, PATHOGENESIS, FIBROSIS, ENZYME, CELLS, DNA
  • Marmara University Affiliated: Yes

Abstract

Aims: To investigate the effect of sildenafil citrate (SIL) on the extent of tissue integrity, oxidant-antioxidant status and apoptosis in rats with colitis.