The effect of phosphodiesterase-5 inhibition by sildenafil citrate on inflammation and apoptosis in rat experimental colitis

Karakoyun B., Uslu Ü., Ercan F., Aydın M. Z., Yüksel M., Velioğlu Öğünç A., ...Daha Fazla

LIFE SCIENCES, cilt.89, ss.402-407, 2011 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.lfs.2011.07.005
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.402-407
  • Anahtar Kelimeler: Nitric oxide, Phosphodiesterase, Sildenafil citrate, Trinitrobenzenesulphonic acid, TRINITROBENZENE SULFONIC-ACID, BOWEL-DISEASE, REACTIVE OXYGEN, MODEL, COLON, PATHOGENESIS, FIBROSIS, ENZYME, CELLS, DNA
  • Marmara Üniversitesi Adresli: Evet

Özet

Aims: To investigate the effect of sildenafil citrate (SIL) on the extent of tissue integrity, oxidant-antioxidant status and apoptosis in rats with colitis.