Effect of harmane, an endogenous beta-carboline, on learning and memory in rats

Celikyurt I. K., UTKAN T., GÖÇMEZ S. S., Hudson A., ARICIOĞLU F.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.103, sa.3, ss.666-671, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.pbb.2012.10.011
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.666-671
  • Anahtar Kelimeler: Harmane, Learning, Memory, Three panel runway, Passive avoidance, Rats, PASSIVE-AVOIDANCE TEST, WORKING-MEMORY, BENZODIAZEPINE RECEPTORS, INHIBITORY AVOIDANCE, CHOLINERGIC SYSTEM, INDUCED AMNESIA, BRAIN, MICE, ACQUISITION, INVOLVEMENT
  • Marmara Üniversitesi Adresli: Evet

Özet

Our aim was to investigate the effects of acute harmane administration upon learning and memory performance of rats using the three-panel runway paradigm and passive avoidance test. Male rats received harmane (2.5, 5, and 7.5 mg/kg, i.p.) or saline 30 min. before each session of experiments. In the three panel runway paradigm, harmane did not affect the number of errors and latency in reference memory. The effect of harmane on the errors of working memory was significantly higher following the doses of 5 mg/kg and 7.5 mg/kg. The latency was changed significantly at only 7.5 mg/kg in comparison to control group. Animals were given pre-training injection of harmane in the passive avoidance test in order to determine the learning function. Harmane treatment decreased the retention latency significantly and dose dependently, which indicates an impairment in learning. In this study, harmane impaired working memory in three panel runway test and learning in passive avoidance test. As an endogenous bioactive molecule, harmane might have a critical role in the modulation of learning and memory functions. (c) 2012 Elsevier Inc. All rights reserved.