Anti-inflammatory effect of meloxicam on experimental vasospasm in the rat femoral artery

Hakan T., Berkman M. Z., Ersoy T., Karatas I., San T., Arbak S.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.15, sa.1, ss.55-59, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.jocn.2006.10.010
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.55-59
  • Anahtar Kelimeler: cerebral vasospasm, femoral artery, inflammation, meloxicam, subarachnoid haemorrhage, EXPERIMENTAL SUBARACHNOID HEMORRHAGE, DELAYED CEREBRAL VASOSPASM, BASILAR ARTERY, MODEL, INFLAMMATION, INHIBITION, IBUPROFEN, CYCLOOXYGENASE-2, PROSTACYCLIN, PREVENTION
  • Marmara Üniversitesi Adresli: Evet

Özet

Cerebral vasospasm influences morbidity and mortality following subarachnoid haemorrhage (SAH). Inflammation is believed to play a role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. We investigated the effect of meloxicam on a rat femoral artery vasospasm model using the radial wall thickness and cross-sectional lumen area as parameters under light, scanning and transmission electron microscopy examination. Rats were randomly separated into SAH, SAH + meloxicam and control groups. Rats in the SAH + meloxicam group were given meloxicam at 2 mg/kg daily for 7 days. Femoral arteries were examined by light microscopy and scanning and transmission electron microscopy, and for morphometric analysis. A statistically significant difference (p < 0.001) was detected between the SAH and SAH + meloxicam groups. Meloxicam treatment reduced ultrastructural and morphometric vasospastic changes. These findings support the hypothesis that inflammation may play a role in the pathophysiologyical pathways of post-haemorrhagic cerebral vasospasm. (C) 2006 Elsevier Ltd. All rights reserved.