Signalling functions of alpha-tocopherol in smooth muscle cells


Azzi A., Boscoboinik D., Clement S., Ozer N., Ricciarelli R., Stocker A., ...Daha Fazla

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, cilt.67, sa.5, ss.343-349, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 5
  • Basım Tarihi: 1997
  • Dergi Adı: INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.343-349
  • Anahtar Kelimeler: alpha-tocopherol, vitamin E, protein kinase C, vascular smooth muscle cell, cell proliferation, protein phosphatase, oxidative stress, PROTEIN-KINASE-C, VITAMIN-E CONSUMPTION, CORONARY-DISEASE, CAROTID-ARTERY, PROLIFERATION, ATHEROSCLEROSIS, ANTIOXIDANT, RAT, PHOSPHORYLATION, PATHOGENESIS
  • Marmara Üniversitesi Adresli: Evet

Özet

alpha-Tocopherol but not beta-tocopherol, activates protein phosphatase 2A, decreases protein kinase C activity and attenuates smooth muscle cell proliferation at physiological concentrations. beta-Tocopherol prevents the effects of alpha-tocopherol. Inhibition of protein kinase C alpha but not of the other isoforms, by the inhibitor Go6976 prevents the effect of alpha-tocopherol. Protein kinase C alpha, immunoprecipitated from alpha-tocopherol treated cells, is less phosphorylated and inactive. It is proposed that the specific activation of protein phosphatase 2A by alpha-tocopherol results in dephosphorylation and inactivation of protein kinase C alpha. Finally, this cascade of events leads to smooth muscle cell proliferation inhibition.