Signalling functions of alpha-tocopherol in smooth muscle cells


Azzi A., Boscoboinik D., Clement S., Ozer N. , Ricciarelli R., Stocker A., ...Daha Fazla

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, cilt.67, sa.5, ss.343-349, 1997 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 67 Konu: 5
  • Basım Tarihi: 1997
  • Dergi Adı: INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
  • Sayfa Sayıları: ss.343-349

Özet

alpha-Tocopherol but not beta-tocopherol, activates protein phosphatase 2A, decreases protein kinase C activity and attenuates smooth muscle cell proliferation at physiological concentrations. beta-Tocopherol prevents the effects of alpha-tocopherol. Inhibition of protein kinase C alpha but not of the other isoforms, by the inhibitor Go6976 prevents the effect of alpha-tocopherol. Protein kinase C alpha, immunoprecipitated from alpha-tocopherol treated cells, is less phosphorylated and inactive. It is proposed that the specific activation of protein phosphatase 2A by alpha-tocopherol results in dephosphorylation and inactivation of protein kinase C alpha. Finally, this cascade of events leads to smooth muscle cell proliferation inhibition.