Prognostic significance of necrosis in ampullary carcinomas.

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Akar K. E., Bagci P.

Irish journal of medical science, cilt.193, sa.5, ss.2179-2185, 2024 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 193 Sayı: 5
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s11845-024-03740-3
  • Dergi Adı: Irish journal of medical science
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CAB Abstracts
  • Sayfa Sayıları: ss.2179-2185
  • Anahtar Kelimeler: Adenocarcinoma, Ampulla of Vater, Carcinoma, Necrosis, Prognosis
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Marmara Üniversitesi Adresli: Evet

Özet

Background/aims

Necrosis is an important pathological feature that reflects high malignancy potential in tumors such as hepatocellular carcinoma and renal cell carcinoma. We aimed to elucidate the prognostic impact of necrosis in ampullary carcinomas.

Materials and methods

We reviewed 101 consecutive cases of ampullary carcinoma for tumor necrosis, types of necrosis, macroscopic and microscopic histopathological subtypes, lymphatic-vascular-perineural invasions, and other histopathological parameters.

Results

Tumor necrosis was present in 19 (18.8%) cases and was identified as an independent poor prognostic indicator in multivariate survival analysis (p = 0.029).

Conclusion

The presence of necrosis in ampullary carcinomas is directly related to vascular and perineural invasion and is a poor prognostic indicator independent of tumor stage. Including the presence of necrosis in the pathology reports of ampullary carcinomas will facilitate risk stratification.