Prognostic significance of necrosis in ampullary carcinomas.

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Akar K. E., Bagci P.

Irish journal of medical science, vol.193, no.5, pp.2179-2185, 2024 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 193 Issue: 5
  • Publication Date: 2024
  • Doi Number: 10.1007/s11845-024-03740-3
  • Journal Name: Irish journal of medical science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CAB Abstracts
  • Page Numbers: pp.2179-2185
  • Keywords: Adenocarcinoma, Ampulla of Vater, Carcinoma, Necrosis, Prognosis
  • Open Archive Collection: AVESIS Open Access Collection
  • Marmara University Affiliated: Yes

Abstract

Background/aims

Necrosis is an important pathological feature that reflects high malignancy potential in tumors such as hepatocellular carcinoma and renal cell carcinoma. We aimed to elucidate the prognostic impact of necrosis in ampullary carcinomas.

Materials and methods

We reviewed 101 consecutive cases of ampullary carcinoma for tumor necrosis, types of necrosis, macroscopic and microscopic histopathological subtypes, lymphatic-vascular-perineural invasions, and other histopathological parameters.

Results

Tumor necrosis was present in 19 (18.8%) cases and was identified as an independent poor prognostic indicator in multivariate survival analysis (p = 0.029).

Conclusion

The presence of necrosis in ampullary carcinomas is directly related to vascular and perineural invasion and is a poor prognostic indicator independent of tumor stage. Including the presence of necrosis in the pathology reports of ampullary carcinomas will facilitate risk stratification.