Pancreatic involvement in cystic fibrosis

ÖZEN ALAHDAB Y., DUMAN D.

MINERVA MEDICA, cilt.107, sa.6, ss.427-436, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 107 Sayı: 6
  • Basım Tarihi: 2016
  • Dergi Adı: MINERVA MEDICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.427-436
  • Anahtar Kelimeler: Cystic fibrosis, Exocrine pancreatic insufficiency, Pancreatitis, TRANSMEMBRANE CONDUCTANCE REGULATOR, FECAL ELASTASE-1, PULMONARY-FUNCTION, PHENOTYPE CORRELATIONS, BICARBONATE SECRETION, EXOCRINE PANCREAS, CHANGING FACE, MURINE MODEL, LUMINAL PH, GENE
  • Marmara Üniversitesi Adresli: Evet

Özet

Cystic fibrosis (CF) is an important genetic disorder that usually manifests in early childhood. Better understanding and improved care of CF patients in our current practice with pancreatic enzyme replacement therapy and nutritional support has enabled physicians to see them more frequently from any age groups. After the lungs, pancreas is the most important organ involved with CF. Its most frequently affected component is the exocrine pancreas while endocrine functions may also be deranged. Parenchymal damage as acute or chronic pancreatitis may also develop. Herein, we aimed to outline the types of the disease, clinical picture, diagnosis and genetic aspect of the CF linked with the pancreatic involvement.