Synergistic Combination of Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid and Natural Flavonoid Curcumin Exhibits Anticancer and Antibacterial Activity.

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Altundağ E., Toprak K., Şanlıtürk G., Güran M., Özbilenler C., Kerküklü N., ...More

Anti-cancer agents in medicinal chemistry, vol.21, pp.1301-1308, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2021
  • Doi Number: 10.2174/1871520620666201006141317
  • Journal Name: Anti-cancer agents in medicinal chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1301-1308
  • Keywords: B-CPAP cells, SAHA, curcumin, apoptosis, anti-microbial activity, histone deacetylase inhibitor
  • Marmara University Affiliated: Yes

Abstract

Background and Objective: Curcumin is an effective anti-cancer agent used in thyroid cancer treatments. However, its use in clinical applications is limited due to low solubility and bioavailability. In this study, a novel combination strategy was applied by combining curcumin with Suberoylanilide Hydroxamic Acid (SAHA) to increase both bioavailability of curcumin and the efficiency of SAHA, which have limited efficiency when used alone.