Synergistic Combination of Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid and Natural Flavonoid Curcumin Exhibits Anticancer and Antibacterial Activity.

Altundağ E., Toprak K., Şanlıtürk G., Güran M., Özbilenler C., Kerküklü N., ...More

Anti-cancer agents in medicinal chemistry, vol.21, pp.1301-1308, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2021
  • Doi Number: 10.2174/1871520620666201006141317
  • Title of Journal : Anti-cancer agents in medicinal chemistry
  • Page Numbers: pp.1301-1308
  • Keywords: B-CPAP cells, SAHA, curcumin, apoptosis, anti-microbial activity, histone deacetylase inhibitor


Background and Objective: Curcumin is an effective anti-cancer agent used in thyroid cancer treatments. However, its use in clinical applications is limited due to low solubility and bioavailability. In this study, a novel combination strategy was applied by combining curcumin with Suberoylanilide Hydroxamic Acid (SAHA) to increase both bioavailability of curcumin and the efficiency of SAHA, which have limited efficiency when used alone.