THE EFFECT OF AGMATINE ON SPIKE-AND-WAVE DISCHARGES IN A GENETIC MODEL OF ABSENCE EPILEPSY

---

Akman O., UTKAN T., ARICIOĞLU F., ATEŞ N., KARSON A.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.85, ss.15-21, 2022 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 85
• Basım Tarihi: 2022
• Doi Numarası: 10.26650/iuitfd.2021.904146
• Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.15-21
• Anahtar Kelimeler: Agmatine, absence epilepsy, wistar albino glaxo rijswijk rats, RECEPTOR ANTAGONIST, RAT MODEL, WAG/RIJ RATS, NITRIC-OXIDE, ANIMAL-MODEL, INVOLVEMENT, SEIZURES, INHIBITION
• Marmara Üniversitesi Adresli: Evet

Özet

Objective: Studies on the actions of exogenous agmatine in experimental models have shown its anti-convulsant effects. However, there are no findings regarding the influence of agmatine on absence epilepsy. Therefore, we investigated the effects of the agmatine in the occurrence of spike-and-wave discharges (SWDs) in the Wistar Albino Glaxo Rijswijk rats (WAG/Rij) model of genetic absence epilepsy.