Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS)

Aker R., Tezcan K., Carcak N., Sakalli E., Akin D., ONAT F.

EPILEPSY RESEARCH, cilt.89, sa.1, ss.7-16, 2010 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.eplepsyres.2009.10.013
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7-16
  • Anahtar Kelimeler: Cortical focus, Limbic epilepsy, Circuitry, Amygdala, Temporal lobe, SWD, IDIOPATHIC GENERALIZED EPILEPSY, TEMPORAL-LOBE, THALAMIC NUCLEI, SEIZURES, MODEL, COEXISTENCE, DISCHARGES, MECHANISMS, EXPRESSION, NEURONS
  • Marmara Üniversitesi Adresli: Evet

Özet

Models of genetic absence epilepsy are resistant to secondary generalization of focal limbic seizures. This correlates with the postnatal development of spike-and-wave discharges (SWDs), a hallmark of absence seizures arising from a cortical focus in the perioral region of somatosensory cortex. Ethosuximide injected at this site suppresses SWDs. The effect of this suppression on kindling in "Genetic Absence Epilepsy Rats from Strasbourg" (GAERS), has been compared for postnatal 30 day (PN30) rats having immature SWDs and adult (>4 months) rats having mature SWDs.