Evaluation of the Association between Programmed Cell Death-1 Gene Polymorphisms and Hepatocellular Carcinoma Susceptibility in Turkish Subjects. A Pilot Study

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Demirci A. F., Demirtas C. O., Eren F., Yilmaz D., Keklikkiran C., Ozdogan O. C., ...Daha Fazla

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, cilt.29, sa.4, ss.617-622, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.15403/jgld-2623
  • Dergi Adı: JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.617-622
  • Anahtar Kelimeler: hepatocellular carcinoma, programmed cell death-1, single nucleotide polymorphisms, susceptibility, DEATH-1 GENE, LIGAND 1, EXPRESSION, PD-1, PROGRESSION, POPULATION, CANCER, PD1
  • Marmara Üniversitesi Adresli: Evet

Özet

Background & Aims: Programmed cell death-1 (PD-1) has a vital role in regulating T-cell function, and immune escape mechanism of cancer cells. It was shown that there could be a relationship between single nucleotide polymorphisms (SNPs) in the PD-I gene and susceptibility to hepatocellular carcinoma (MCC) based on various studies. We aimed to investigate the role of three SNPs within the PD-1 gene in susceptibility to HCC in the Turkish population.