NT-proBNP levels and mortality in a genera population-based cohort from Turkey: a long-term follow-up study

Simsek M. A., Degertekin M., Cabbar A. T., Aslanger E., Ozveren O., Aydin S., ...More

BIOMARKERS IN MEDICINE, vol.12, no.10, pp.1073-1081, 2018 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 10
  • Publication Date: 2018
  • Doi Number: 10.2217/bmm-2018-0120
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1073-1081
  • Keywords: all-cause mortality, cardiovascular epidemiology, cardiovascular mortality, general population, NT-proBNP, BRAIN NATRIURETIC PEPTIDE, CARDIOVASCULAR EVENTS, HEART-FAILURE, BIOMARKERS, RISK, PREDICTORS, DEATH, MEN
  • Marmara University Affiliated: Yes


Aim: We investigated the relationship between NT-ProBNP and mortality in a general population-based cohort. Methods & Results: A total of 2021 out of 4650 participants from previously published HAPPY study were included. Mean follow-up was 84.5 +/- 10.4 months. After adjusting for risk factors, high levels of LogNT-proBNP predicted all-cause death (HR: 3.23; 95% CI: 2.20-4.75; p < 0.001) and cardiovascular death (HR: 3.85; 95% CI: 2.37-6.26; p < 0.001). Regression analysis revealed that LogNT-proBNP was an independent predictor of all-cause death (HR: 2.85; 95% CI: 1.91-4.24; p < 0.001) and cardiovascular death (HR: 3.02; 95% CI: 1.84-4.95; p < 0.001). Conclusion: Our study showed that in long term follow-up, NT-proBNP is associated with increased all-cause and cardiovascular mortality