Swelling and diffusion studies of poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels in water and aqueous solutions of drugs

Tasdelen B., Kayaman-Apohan N., Guven O., Baysal B.

JOURNAL OF APPLIED POLYMER SCIENCE, vol.91, no.2, pp.911-915, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 91 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1002/app.13223
  • Journal Name: JOURNAL OF APPLIED POLYMER SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.911-915
  • Keywords: hydrogels, radiation, diffusion, POLYMERS, RELEASE, TRANSPORT
  • Marmara University Affiliated: Yes

Abstract

N-Isopropylacrylamide/itaconic acid hydrogels (NIPAAm/IA) containing different amounts of itaconic acid prepared by irradiating with gamma-radiation were used in experiments on swelling and diffusion of the model drugs methylene blue, lidocaine, and sildenafil citrate (VIAGRA). The NIPAAm/IA hydrogels containing 0-3 mol % itaconic acid irradiated at 48 kGy has been used for swelling and diffusion studies in water and aqueous solutions containing the above-mentioned model drugs. For these hydrogels, swelling studies indicated that swelling increased with the following order: water > lidocaine > methylene blue > VIAGRA. Diffusions of water and the drugs within hydrogels were found to be non-Fickian in character. (C) 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 911-915, 2004.