Real-world assessment of quality-of-life in patients with breast cancer treated with adjuvant endocrine therapy
FUTURE ONCOLOGY, cilt.18, ss.2425-2439, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18
- Basım Tarihi: 2022
- Doi Numarası: 10.2217/fon-2021-1322
- Dergi Adı: FUTURE ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.2425-2439
- Anahtar Kelimeler: adjuvant endocrine therapy, breast cancer, FACT-B, FACT-G, quality-of-life, FUNCTIONAL ASSESSMENT, POSTMENOPAUSAL WOMEN, SYMPTOM BURDEN, FACT-B, TAMOXIFEN, SURVIVORS, EXEMESTANE, OUTCOMES, IMPACT, TRIAL
- Marmara Üniversitesi Adresli: Evet
Özet
Objective: The aim of this study was to investigate quality-of-life (QoL) in breast cancer (BC) patients treated with adjuvant endocrine therapy (AET). Methods: We designed a cross-sectional study of 233 BC patients treated with AET and used the Functional Assessment of Cancer Therapy - Breast questionnaire. Results: No significant difference was observed between endocrine agents. Duration of AET did not affect QoL. In the entire cohort, multivariate analysis determined age (p = 0.034) and switching treatment from tamoxifen to aromatase inhibitors (p = 0.049) as significant positive coefficients of QoL, while comorbidity (p = 0.072) tended to be associated with lower scores. Education level (p = 0.001) and chemotherapy (p = 0.04) were significant predictors of QoL in the tamoxifen group, while comorbidity (p = 0.04), surgery type (p = 0.02), radiotherapy (p = 0.006) and stage (p = 0.009) had a significant impact on QoL in aromatase inhibitors group. Conclusion: Evaluating the well-being of BC patients by QoL questionnaires is of great importance to identify particular subgroups that may require supportive care.