Local aromatase activity alterations in breast cancer tissues: A potential way of decision support for clinicians


Tuzuner M. B. , ÖZTÜRK T., İLVAN Ş., TURNA Z. H. , YURDUN T. , Yilmaz-Aydogan H., ...More

EXPERIMENTAL AND MOLECULAR PATHOLOGY, vol.118, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118
  • Publication Date: 2021
  • Doi Number: 10.1016/j.yexmp.2020.104574
  • Title of Journal : EXPERIMENTAL AND MOLECULAR PATHOLOGY

Abstract

Background and aims: It is becoming evident that local estrogen exposure is important in postmenopausal breast cancer patients. The microenvironment is established by breast stromal cells based on communication with tumor cells that is essential to cancer development, invasion, and metastasis. Here we investigated aromatase activity levels in both tumor and matched stromal tissues by showing their impact on the manufacturing of local estrogen and tumor progression in cases of invasive ductal carcinoma (IDC).