Behcet's disease in patients with chronic myelogenous leukemia: Possible role of interferon-alpha treatment in the occurrence of Behcet's symptoms

BudakAlpdogan T., Demircay Z., Alpdogan O., DİRESKENELİ R. H., Ergun T., Bayik M., ...Daha Fazla

ANNALS OF HEMATOLOGY, cilt.74, sa.1, ss.45-48, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 1
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1007/s002770050255
  • Dergi Adı: ANNALS OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.45-48
  • Anahtar Kelimeler: Behcet's disease, chronic myelogenous leukemia, pathergy reaction, adverse effect, alpha-interferon, CHRONIC MYELOID-LEUKEMIA, PROGENITOR CELLS, THERAPY
  • Marmara Üniversitesi Adresli: Evet

Özet

Two patients with chronic myelogenous leukemia (CML) who developed characteristic features of Behcet's disease (ED) during alpha-interferon (IFN-alpha) treatment and another patient who had a diagnosis of ED preceding CML are presented. In the first two patients, features of ED appeared 6 months after the initiation of IFN-alpha treatment; they included recurrent oral aphthae, genital ulceration, arthritis, folliculitis, and a positive skin pathergy test. The third patient, however, had a diagnosis of Behcet's disease 4 years before diagnosis of Philadelphia-positive CML. We prospectively examined the skin pathergy reaction in a group of patients with CML, multiple myeloma, and hairy cell leukemia both before and after IFN-alpha treatment and found two additional patients with CML who developed a positive skin pathergy test following IFN-alpha treatment.