SCARB1 Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease

Ayhan H., Gormus U., Isbir S., Yilmaz S. G., İSBİR T.

IN VIVO, cilt.31, sa.5, ss.873-876, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.21873/invivo.11141
  • Dergi Adı: IN VIVO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.873-876
  • Anahtar Kelimeler: Coronary artery disease, HDL subfractions, SCARB1, polymorphism, DENSITY-LIPOPROTEIN SUBFRACTIONS, SCAVENGER RECEPTOR, SR-BI, IDENTIFICATION, CHOLESTEROL, SEVERITY, RISK
  • Marmara Üniversitesi Adresli: Evet

Özet

Background/Aim: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids. Patients and Methods: Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions. Results: According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02). Conclusion: The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL subfraction.