SCARB1 Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease


Ayhan H., Gormus U., Isbir S., Yilmaz S. G. , İSBİR T.

IN VIVO, vol.31, no.5, pp.873-876, 2017 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.21873/invivo.11141
  • Title of Journal : IN VIVO
  • Page Numbers: pp.873-876
  • Keywords: Coronary artery disease, HDL subfractions, SCARB1, polymorphism, DENSITY-LIPOPROTEIN SUBFRACTIONS, SCAVENGER RECEPTOR, SR-BI, IDENTIFICATION, CHOLESTEROL, SEVERITY, RISK

Abstract

Background/Aim: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids. Patients and Methods: Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions. Results: According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02). Conclusion: The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL subfraction.