The effect of doxazosin and sildenafil citrate combination on bladder tissue contractility, alpha adrenergic receptor, and iNOS subtype expression in a male rat model of partially bladder outlet obstruction

Gumrah A., TANIDIR Y., TİNAY İ., ÖZYÜREK M., TARCAN T.

NEUROUROLOGY AND URODYNAMICS, vol.36, no.6, pp.1479-1487, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1002/nau.23155
  • Journal Name: NEUROUROLOGY AND URODYNAMICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1479-1487
  • Keywords: bladder outlet obstruction, doxazosin, isometric tension studies, receptors, sildenafil, URINARY-TRACT SYMPTOMS, NITRIC-OXIDE SYNTHASE, BENIGN PROSTATIC HYPERPLASIA, PARTIAL URETHRAL OBSTRUCTION, SMOOTH-MUSCLE-CELLS, ERECTILE DYSFUNCTION, GUANYLYL CYCLASE, MESSENGER-RNA, HUMAN BPH, INHIBITORS
  • Marmara University Affiliated: Yes

Abstract

AimsOur aim was to investigate the effects of doxazosin, sildenafil, and their combination on bladder tissue contractility and adrenergic receptor (AR) and inducible nitric oxide synthase (iNOS) expression utilizing a male rat model of partial urethral obstruction (PUO).