The effect of doxazosin and sildenafil citrate combination on bladder tissue contractility, alpha adrenergic receptor, and iNOS subtype expression in a male rat model of partially bladder outlet obstruction

Gumrah A., TANIDIR Y., TİNAY İ., ÖZYÜREK M., TARCAN T.

NEUROUROLOGY AND URODYNAMICS, cilt.36, sa.6, ss.1479-1487, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/nau.23155
  • Dergi Adı: NEUROUROLOGY AND URODYNAMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1479-1487
  • Anahtar Kelimeler: bladder outlet obstruction, doxazosin, isometric tension studies, receptors, sildenafil, URINARY-TRACT SYMPTOMS, NITRIC-OXIDE SYNTHASE, BENIGN PROSTATIC HYPERPLASIA, PARTIAL URETHRAL OBSTRUCTION, SMOOTH-MUSCLE-CELLS, ERECTILE DYSFUNCTION, GUANYLYL CYCLASE, MESSENGER-RNA, HUMAN BPH, INHIBITORS
  • Marmara Üniversitesi Adresli: Evet

Özet

AimsOur aim was to investigate the effects of doxazosin, sildenafil, and their combination on bladder tissue contractility and adrenergic receptor (AR) and inducible nitric oxide synthase (iNOS) expression utilizing a male rat model of partial urethral obstruction (PUO).