Lipase mediated synthesis of polycaprolactone and its silica nanohybrid

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Akkulak M., Kaptan Y., Aydın Y. A. , Guvenilir Y. A.

PURE AND APPLIED CHEMISTRY, vol.91, pp.957-965, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 91
  • Publication Date: 2019
  • Doi Number: 10.1515/pac-2018-1011
  • Page Numbers: pp.957-965


In this study, rice husk ash (RHA) silanized with 3-glycidyloxypropyl trimethoxysilane was used as support material to immobilize Candida antarctica lipase B. The developed biocatalyst was then utilized in the ring opening polymerization (ROP) of epsilon-caprolactone and in situ development of PCL/Silica nanohybrid. The silanization degree of RHA was determined as 4 % (w) by thermal gravimetric analysis (TGA). Structural investigations and calculation of molecular weights of nanohybrids were realized by proton nuclear magnetic resonance (H-1 NMR). Crystallinity was determined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Scanning Electron Microscopy (SEM) was used for morphological observations. Accordingly, the PCL composition in the nanohybrid was determined as 4%, approximately. Short chained amorphous PCL was synthesized with a number average molecular weight of 4400 g/mol and crystallinity degree of 23%. In regards to these properties, synthesized PCL/RHA composite can find use biomedical applications.