Akademik Veri Yönetim Sistemi
Fertility and Sterility, cilt.66, sa.2, ss.216-219, 1996 (Scopus)
Objective: To compare the efficacy of two antiandrogens, cyproterone acetate (CPA) and spironolactone, in the treatment of hirsutism. Design: Prospective randomized single-blinded study. Setting: A tertiary hirsutism clinic. Patients: Forty-two premenopausal patients with hirsutism were selected. Interventions: Subjects were randomized to receive either 100 mg spironolactone and an oral contraceptive (OC) containing 150 μg desogestrel and 30 μg ethinyl E2 or 50 mg CPA daily on days 1 to 10 of the menstrual cycle, which was administered with 35 μg ethinyl E2 daily on days 1 to 21. Main Outcome Measures: Hirsutism scores were measured according to Ferriman- Gallwey scoring system and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters. Results: Hirsutism scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in CPA and spironolactone group were as follows: 19.23% ± 14.77% and 24.48% ± 14.27% at 3 months; 39.01% ± 19.77% and 37.46% ± 16.90% at 6 months; and 51.89% ± 20.87% and 46.39% ± 16.10% at 9 months, respectively. There was a trend toward a better response with CPA treatment, which did not achieve significance. None of the patients stopped treatment because of side effects. Conclusion: The present data suggest that both spironolactone and CPA were similarly effective in treatment of hirsutism.