Objective: Thyroid cancer is the most common endocrine malignancy. Molecular mechanisms underlying this disorder are heterogeneous and need to be clarified. Different polymorphic variants of the p53 gene have been demonstrated to be in association with several human malignancies. Of those, codon 72 polymorphism is the most extensively studied variant; however, so far only two studies have investigated the association of this polymorphism with thyroid cancer. Thus, we aimed to investigate the association of p53 codon 72 polymorphism with thyroid cancer in a group of Turkish patients.