Neurofeedback therapy is a form of training where brainwave patterns can be modified by operant conditioning techniques. Neurofeedback therapy practitioners advocate the use of NF in several clinical conditions and even for performance enhancing in healthy subjects. However, the current published data lack strong controls, hence it has been criticisized by mainstream scientists and researchers. The NF field carries potentials for risks of having inappropriate treatments by lay practitioners that might cause severe adverse events in patients. These adverse events and iatrogenic reactions have often been ignored by the NF practitioners. Here, we emphasize the importance of good clinical practice and ethical guidelines that would address problems in standards of practice and ethical concerns in the field.