Sex hormone binding globulin gene polymorphisms and metabolic syndrome in postmenopausal Turkish women

Creative Commons License

SÜNBÜL M., EREN F., NACAR C., Agirbasli M.

CARDIOLOGY JOURNAL, cilt.20, sa.3, ss.287-293, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5603/cj.2013.0074
  • Dergi Adı: CARDIOLOGY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.287-293
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Insulin resistance is associated with obesity, glucose intolerance or diabetes, hypertension, dyslipidemia, and cardiovascular disease. Constellation of these risk factors is called metabolic syndrome (MetS). MetS is common among postmenopausal women. Low sex hormone binding globulin (SHBG) levels associate with an increased risk of MetS in postmenopausal women. Variations in SHBG gene associate with low levels of circulating SHBG levels. We aim to study the association between SHBG gene polymorphisms - rs1799941 (A/G) and rs6257 (T/C) - with MetS among postmenopausal women.