Potential Cost-Effectiveness of Pneumococcal Conjugate Vaccine (PCV) in Turkey

Turel O., Kisa A., McIntosh E. D. G., Bakir M.

VALUE IN HEALTH, cilt.16, sa.5, ss.755-759, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jval.2013.03.1632
  • Dergi Adı: VALUE IN HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.755-759
  • Anahtar Kelimeler: burden of disease, children, cost-effectiveness, pneumonia, vaccines, ACUTE OTITIS-MEDIA, STREPTOCOCCUS-PNEUMONIAE, HAEMOPHILUS-INFLUENZAE, CHILDREN YOUNGER, PROTEIN-D, DISEASE, IMMUNIZATION, MENINGITIS, PREVENTION, EFFICACY
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Pneumococcal infection is an important and preventable cause of morbidity and mortality. The Turkish government introduced 7-valent pneumococcal conjugate vaccine (PCV) into the national immunization program in 2009. This suggests that replacing 7-valent PCV with a higher-valent version could at least maintain "standard of care" if not improve it, and that it could be affordable. Objectives and Methods: The aim of this analysis was to assess the potential direct cost-effectiveness of 13-valent PCV in Turkey, a country with a birth cohort of 1.4 million, against a "no vaccine" state, against the default 7-valent PCV state, and against a 10-valent PCV state, using a published cohort model with a 5-year horizon. Results and Conclusions: The cost per life-year gained is below the 1 x per-capita gross domestic product threshold across large changes in key input parameters, indicating that the model is stable and suggesting that any PCV would be very cost-effective in a Turkish national pediatric immunization schedule.