3D printing of Osage orange extract/Chitosan scaffolds for soft tissue engineering

SAATÇİOĞLU E., KOYUN M., ULAĞ S., ŞAHİN A., YILMAZ B., AKSU M. B., ...Daha Fazla

FOOD HYDROCOLLOIDS FOR HEALTH, cilt.1, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.fhfh.2021.100039
  • Dergi Adı: FOOD HYDROCOLLOIDS FOR HEALTH
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Anahtar Kelimeler: Chitosan, Maclura pomifera, Osage orange, Wound healing, 3D printing
  • Marmara Üniversitesi Adresli: Evet

Özet

© 2021 The AuthorsIn this study, three-dimensional tissue scaffolds were fabricated using a 3D printing process. Chitosan (CS) was used as a matrix polymer, and Osage orange extract (OGE) with different amounts was added as a bioactive material. The scaffolds were characterized by SEM, FTIR, tensile testing, antibacterial, and biocompatibility tests. The SEM images revealed that scaffolds had homogeneous morphology, and the size of the pores ranged from 160 µm to 270 µm. FTIR spectrum of the extracted Osage Orange confirmed the successful extraction of the Osage Orange. The OGE addition decreased the swelling capacity of the CS scaffold proportionally. Biocompatibility results proved the biostability properties of the scaffolds. According to the results, the antibacterial activity of the scaffolds against the Staphylococcus Aureus (S. aureus) and Enterococcus Faecalis (E. faecalis) should be provided after detailed optimization.