Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice


Ulusoy C., Zibandeh N., Yildirim S., Trakas N., Zisimopoulou P., Kucukerden M., ...More

JOURNAL OF NEUROINFLAMMATION, vol.12, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2015
  • Doi Number: 10.1186/s12974-015-0451-0
  • Title of Journal : JOURNAL OF NEUROINFLAMMATION

Abstract

Background: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ), mostly associated with acetylcholine receptor (AChR) antibodies. Around 5-10 % of MG patients show antibodies to muscle-specific tyrosine kinase (MuSK). Mesenchymal stem cell (MSC) administration has been shown to ameliorate muscle weakness in the experimental autoimmune myasthenia gravis (EAMG) model induced by AChR immunization.