Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice

Ulusoy C., Zibandeh N., Yildirim S., Trakas N., Zisimopoulou P., Kucukerden M., ...Daha Fazla

JOURNAL OF NEUROINFLAMMATION, cilt.12, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1186/s12974-015-0451-0
  • Dergi Adı: JOURNAL OF NEUROINFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Myasthenia gravis, Muscle-specific kinase, Mesenchymal stem cells, Dendritic cells, Autoimmunity, AUTOIMMUNE MYASTHENIA-GRAVIS, TYROSINE KINASE MUSK, BONE-MARROW, CLINICAL-APPLICATIONS, SUPPRESSION, EXPRESSION, GAMMA
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ), mostly associated with acetylcholine receptor (AChR) antibodies. Around 5-10 % of MG patients show antibodies to muscle-specific tyrosine kinase (MuSK). Mesenchymal stem cell (MSC) administration has been shown to ameliorate muscle weakness in the experimental autoimmune myasthenia gravis (EAMG) model induced by AChR immunization.