PIK3CA and TP53 MUTATIONS and SALL4, PTEN and PIK3R1 GENE EXPRESSION LEVELS in BREAST CANCER

DİRİCAN E., ERBARUT SEVEN İ., KAYA H., UĞURLU M. Ü., PEKER EYÜBOĞLU İ., GÜLLÜOĞLU M. B., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY, cilt.45, ss.515-523, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/tjb-2019-0137
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.515-523
  • Anahtar Kelimeler: Breast cancer, PI3K, PIK3CA, HRM, Candidate genes, CELL-PROLIFERATION, ASSOCIATION
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: A high frequency of PI3K signalling pathway abnormalities and TP53 mutations are critical in the development and progression of breast cancer (BCa). We aimed to detect PIK3CA and TP53 mutations via an expression analysis of PIK3R1, PTEN and SALL4 and correlate the expression of these genes with clinical parameters of BCa.