The effect of vitamin D supplementation on pain, quality of life, and nerve conduction studies in women with chronic widespread pain

Akyuz G., ŞANAL TOPRAK C., YAĞCI İ., Giray E., Kuru-Bektasoglu P.

INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH, cilt.40, sa.1, ss.76-83, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1097/mrr.0000000000000211
  • Dergi Adı: INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.76-83
  • Anahtar Kelimeler: chronic widespread pain, nerve conduction study, quality of life, treatment, vitamin D insufficiency, D DEFICIENCY, PERIPHERAL NEUROPATHY, HYPOVITAMINOSIS-D, PREVENTION, OUTCOMES
  • Marmara Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the effects of vitamin D supplementation on pain, quality of life, and nerve conduction studies (NCSs) in women with chronic widespread pain (CWP) diagnosed with Vitamin D insufficiency. Thirty-three female participants with CWP and vitamin D insufficiency were included in this open-label trial. They were evaluated by routine NCSs in upper and lower limbs, pain scales, and the Nottingham Health Profile before and 8 weeks after starting vitamin D supplementation therapy. The P-value was adjusted to account for the number of comparisons performed in each assessment. After 8 weeks of treatment, participants reported significantly lower pain scores (P=0.000). The total Nottingham Health Profile score and subscores for pain, emotional reactions, and physical activity domains were significantly lower (0.000 <= P <= 0.008). However, no statistically significant changes in NCSs were detected, except trends toward increases in the amplitudes of left median and ulnar sensory nerve potentials and a decrease in the distal latency of the right median sensory potential (0.01 <= P <= 0.04). Vitamin D supplementation therapy decreased pain and increased quality of life without significantly affecting nerve conduction in patients with CWP. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.