Synthesis and preliminary anticancer activity of new 1,4-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-5H-1,2,4-triazoline-5-thiones

Duran A., Dogan H., Rollas S.

FARMACO, cilt.57, sa.7, ss.559-564, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 7
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0014-827x(02)01248-x
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.559-564
  • Anahtar Kelimeler: 1,2,4-triazoline-5-thione derivatives, synthesis, anticancer activity, STRUCTURE ELUCIDATION
  • Marmara Üniversitesi Adresli: Hayır

Özet

1,4-Dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-5H-L2,4-triazolinc-5-thiones were synthesized. The structures of original eight compounds were confirmed by elemental analysis,H-1 NMR and mass spectral methods. One of the compounds (3a) was tested in vitro for its anticancer activity against 52 human tumor cell lines. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.