Serum TNF-, sCD8 and sIL-2R levels in childhood tuberculosis

Barlan I., Başaran M., Bakır M., Tükenmez F., Bekiroğlu G. N.

INFECTION, vol.23, no.4, pp.237-239, 1995 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 1995
  • Doi Number: 10.1007/bf01781205.
  • Journal Name: INFECTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.237-239
  • Marmara University Affiliated: Yes

Abstract

In this study we have determined the serum tumor necrosis factor-alpha (TNF-alpha), soluble CD8 (sCD8) and soluble interleukin-2 receptor (sIL-2R) levels in children with active pulmonary tuberculosis (n = 66) and healthy controls (n = 20). Measurable serum TNF-alpha levels were detected in nine of 86 children (10.5%), all of whom belonged to the group with active disease. Serum sCD8 and sIL-2R determinations revealed a significant difference between the group with active pulmonary tuberculosis and the controls (p < 0.05). Deeper insight into the involvement of cytokines and T cells will provide a better understanding