Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis

Tahan V., Eren F., Avsar E., Yavuz D., Yuksel M., Emekli E., ...Daha Fazla

DIGESTIVE DISEASES AND SCIENCES, cilt.52, sa.12, ss.3465-3472, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 12
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s10620-007-9756-x
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3465-3472
  • Anahtar Kelimeler: rosiglitazone, insulin resistance, nonalcoholic fatty liver disease, oral glucose tolerance test, reactive oxygen species, cytokine, interleukin, tumor necrosis factor, GAMMA LIGAND ROSIGLITAZONE, STELLATE CELL ACTIVATION, CHOLINE-DEFICIENT DIET, INSULIN SENSITIVITY, HEPATIC STEATOSIS, REACTIVE OXYGEN, RECEPTOR-GAMMA, TROGLITAZONE, METHIONINE, TRIGLYCERIDE
  • Marmara Üniversitesi Adresli: Evet

Özet

Rosiglitazone is an insulin-sensitizing agent. We aimed to assess the effects of rosiglitazone on a methionine- and choline-deficient diet (MCDD) model of nonalcoholic steatohepatitis (NASH) in rats. Wistar rats were fed either MCDD or a control diet in the 4-week induction study; they were given saline or 4 mg/kg/day rosiglitazone. After the induction study period, the rats were divided into four groups and fed MCDD or given a control diet for an additional 8 weeks and received saline or rosiglitazone. Serum and tissue samples were obtained. Rosiglitazone improved inflammation in NASH and improved ALT, alkaline phosphatase, and interleukin-6 levels in the induction study and interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha levels in the treatment study. Our preliminary study is the first to show the anti-inflammatory effects of rosiglitazone in NASH. Rosiglitazone's effect on cytokines may be a key mechanism of its anti-inflammatory effect in NASH.