alpha-Lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats

Kolgazi M., Jahovic N., Yueksel M., Ercan F., Alican I.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.22, sa.11, ss.1859-1865, 2007 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 11
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1440-1746.2006.04504.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1859-1865
  • Anahtar Kelimeler: alpha-lipoic acid, colitis, ileitis, rat, trinitrobenzenesulfonic acid (TNBS), REACTIVE OXYGEN, ANTIOXIDANT, MODEL, GLUTATHIONE, METABOLISM, ACTIVATION, LIPOATE, COLON
  • Marmara Üniversitesi Adresli: Evet

Özet

Background and Aim: alpha-Lipoic acid (ALA) has been shown to combat oxidative stress by quenching a variety of reactive oxygen species. It is involved in the regeneration of exogenous and endogenous antioxidants, chelation of metal ions, and repair of oxidized proteins. This study aimed to evaluate the potential beneficial effect of ALA on trinitrobenzenesulfonic acid (TNBS)-induced gut ileitis and colitis in rats.