The molecular targets of diclofenac differs from ibuprofen to induce apoptosis and epithelial mesenchymal transition due to alternation on oxidative stress management p53 independently in PC3 prostate cancer cells

Arisan, Elif; Akar, Remzi; Rencuzogullari, Ozge; Yerlikaya, Pinar; Gurkan, AJDA; Akin, Beyza; Dener, Elif; Kayhan, Ecem; Unsal, Narcin

doi:10.1016/j.prnil.2019.09.003

The molecular targets of diclofenac differs from ibuprofen to induce apoptosis and epithelial mesenchymal transition due to alternation on oxidative stress management p53 independently in PC3 prostate cancer cells

Atıf İçin Kopyala

Arisan E. D., Akar R. O., Rencuzogullari O., Yerlikaya P. O., Gurkan A., Akin B., ...Daha Fazla

PROSTATE INTERNATIONAL, cilt.7, sa.4, ss.156-165, 2019 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 7 Sayı: 4
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.prnil.2019.09.003
Dergi Adı: PROSTATE INTERNATIONAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.156-165
Anahtar Kelimeler: Apoptosis, Diclofenac, Epithelial mesenchymal transition, Ibuprofen, Nonsteroidal antiinflammatory drugs, Prostate cancer, Reactive oxygen species, SIGNALING PATHWAY, BETA-CATENIN, CYCLOOXYGENASE-2, CELECOXIB, EXPRESSION, INHIBITOR, INFLAMMATION, DYSFUNCTION, ACTIVATION, FOXO
Marmara Üniversitesi Adresli: Hayır

Özet

Background: Prostate cancer is the most common type of cancer among men. Studies showed that the regular use of nonsteroidal antiinflammatory drugs might reduce disease progression risk for prostate cancer patients with prostate cancer. We evaluated the effects of ectopic expression of p53 on the biological functions of ibuprofen and diclofenac.