Postoperative Statin Therapy Attenuates the Intensity of Systemic Inflammation and Increases Fibrinolysis After Coronary Artery Bypass Grafting

TETİK, ŞERMİN; AK, KORAY; Sahin, Yucel; Gulsoy, Ozkan; Isbir, Selim; ARSAN, SİNAN; Yardimci, Turay

doi:10.1177/1076029610379398

Postoperative Statin Therapy Attenuates the Intensity of Systemic Inflammation and Increases Fibrinolysis After Coronary Artery Bypass Grafting

Atıf İçin Kopyala

TETİK Ş., AK K., Sahin Y., Gulsoy O., Isbir S., ARSAN S., ...Daha Fazla

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.17, sa.5, ss.526-531, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 5
Basım Tarihi: 2011
Doi Numarası: 10.1177/1076029610379398
Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.526-531
Anahtar Kelimeler: atorvastatin, systemic inflammatory response syndrome, CABG, inflammatory mediators, fibrinolysis, FACTOR PATHWAY INHIBITOR, RESPONSE SYNDROME, PLASMA, CYTOKINES, SIRS, ATORVASTATIN, ASSOCIATION, GUIDELINES, ANTIGEN, SEPSIS
Marmara Üniversitesi Adresli: Evet

Özet

A total of 25 patients undergoing coronary artery bypass grafting (CABG) were included in the study. Patients received statin (20 mg daily) postoperatively for 2 weeks. All analyses were performed at 2 different time points: preoperatively (group 1) and 2 weeks after operation (group 2). Interleukin (IL)-6, IL-8, plasminogen activator inhibitor 1 (PAI-1), tumor necrosis factor alpha (TNF-alpha), tissue plasminogen activator (t-PA) levels, and tissue factor pathway inhibitor (TFPI) were evaluated. Statin treatment caused a significant reduction in the plasma level of PAI-1 (preop: 15.04 +/- 0.13 ng/mL vs postop: 13.89 +/- 2.14 ng/mL; P < .05) and increased t-PA levels (preop: 109.74 +/- 0.13 vs postop: 231.40 +/- 1.22 ng/mL; P < .001). Plasma TNF-alpha and IL-6 levels did not change with treatment. Statin treatment caused a significant reduction in plasma IL-8 level (279.70 +/- 3.42 ng/mL vs postop: 207.18 +/- 3.63 ng/mL, P < .05), and TFPI (4.87 +/- 2.05 ng/mL vs postop: 6.27 +/- 1.25 ng/mL; P < .05). The results demonstrate that atorvastatin attenuates systemic inflammatory reaction after cardiac surgery.