Postoperative Statin Therapy Attenuates the Intensity of Systemic Inflammation and Increases Fibrinolysis After Coronary Artery Bypass Grafting

TETİK Ş., AK K., Sahin Y., Gulsoy O., Isbir S., ARSAN S., ...More

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.17, no.5, pp.526-531, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1177/1076029610379398
  • Journal Name: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.526-531
  • Keywords: atorvastatin, systemic inflammatory response syndrome, CABG, inflammatory mediators, fibrinolysis, FACTOR PATHWAY INHIBITOR, RESPONSE SYNDROME, PLASMA, CYTOKINES, SIRS, ATORVASTATIN, ASSOCIATION, GUIDELINES, ANTIGEN, SEPSIS
  • Marmara University Affiliated: Yes

Abstract

A total of 25 patients undergoing coronary artery bypass grafting (CABG) were included in the study. Patients received statin (20 mg daily) postoperatively for 2 weeks. All analyses were performed at 2 different time points: preoperatively (group 1) and 2 weeks after operation (group 2). Interleukin (IL)-6, IL-8, plasminogen activator inhibitor 1 (PAI-1), tumor necrosis factor alpha (TNF-alpha), tissue plasminogen activator (t-PA) levels, and tissue factor pathway inhibitor (TFPI) were evaluated. Statin treatment caused a significant reduction in the plasma level of PAI-1 (preop: 15.04 +/- 0.13 ng/mL vs postop: 13.89 +/- 2.14 ng/mL; P < .05) and increased t-PA levels (preop: 109.74 +/- 0.13 vs postop: 231.40 +/- 1.22 ng/mL; P < .001). Plasma TNF-alpha and IL-6 levels did not change with treatment. Statin treatment caused a significant reduction in plasma IL-8 level (279.70 +/- 3.42 ng/mL vs postop: 207.18 +/- 3.63 ng/mL, P < .05), and TFPI (4.87 +/- 2.05 ng/mL vs postop: 6.27 +/- 1.25 ng/mL; P < .05). The results demonstrate that atorvastatin attenuates systemic inflammatory reaction after cardiac surgery.