Akademik Veri Yönetim Sistemi
Biology, cilt.14, sa.2, 2025 (SCI-Expanded)
Epilepsy is a brain disorder that causes repeated seizures and can disrupt the body’s ability to urinate properly. This study explored whether a specific diet method called alternate-day fasting, in which animals eat every other day, could help protect the urinary systems of rats with epilepsy. We examined bladder and kidney functions through tissue analysis, biochemical tests, and physiological assessments, focusing on the differences between male and female genetic rat models of epilepsy. Epileptic rats showed signs of damage to the urinary system caused by inflammation and oxidative stress. Alternate-day fasting helped to reduce this damage by lowering inflammation and restoring antioxidant balance. Male rats exhibited more oxidative damage, whereas female rats responded better to alternate-day fasting, likely due to hormonal differences. These results suggest that ADF could be an affordable way to manage urinary problems in epilepsy. Understanding these effects may lead to improved treatments for both sexes and better quality of life for people with chronic diseases.