Developments of 3D polycaprolactone/beta-tricalcium phosphate/collagen scaffolds for hard tissue engineering

aydoğdu M. O., MUTLU B., Kurt M., İNAN A. T., KURUCA D. S., Erdemir G., ...Daha Fazla

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, cilt.55, sa.3, ss.849-855, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s41779-018-00299-y
  • Dergi Adı: JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.849-855
  • Anahtar Kelimeler: Biomaterials, Biomedical engineering, Additive manufacturing, Hard tissue scaffolds, NANOFIBROUS SCAFFOLD
  • Marmara Üniversitesi Adresli: Evet

Özet

3D bioprinting provides an innovative strategy to fabricate a new composite scaffold material consisted in a porous and rough structure with using polycaprolactone (PCL), beta-tricalcium phosphate (beta-TCP), and collagen as a building block for tissue engineering. We investigated the optimization of the scaffold properties based on the beta-TCP concentration using 3D bioprinting method. Computer-aided drawing was applied in order to digitally design the scaffolds while instead of solid filaments, materials were prepared as a blend solution and controlled evaporation of the solvent during the bioprinting was enabled the proper solidification of the scaffolds, and they were successfully produced with well-defined porous structure. This work demonstrated the feasibility of complex PCL/beta-TCP/collagen scaffolds as an alternative in the 3D bioprinting engineering to the fabrication of porous scaffolds for tissue engineering.