This study aims to develop an optimization model for obtaining the maximum benefit from wind power plants (WPPs) to help with reducing external dependence in terms of energy. In this sense, design of experiment and optimization methods are comprehensively combined in the wind energy field for the first time. Existing data from installed WPPs operating in Turkey for the years of 2017 and 2018 are analyzed. Both the individual and interactive effects of controllable factors, namely turbine power (MW), hub height (m) and rotor diameter (m), and uncontrollable factor as wind speed (m/s) on WPPs are investigated with the help of Box-Behnken design. Nonlinear optimization models are utilized to estimate optimum values for each decision variable in order to maximize the amount of energy to be produced for the future. Based on the developed nonlinear optimization models, the optimum results with high desirability value (0.9587) for the inputs of turbine power, hub height, rotor diameter and wind speed are calculated as 3.0670 MW, 108.8424 m, 106.7597 m, and 6.1684 m/s, respectively. The maximum energy output with these input values is computed as 9.952 million kWh per unit turbine, annually. The results of this study can be used as a guideline in the design of new WPPs to produce the maximum amount of energy contributing to supply escalating energy needs by more sustainable and clean ways for the future.