Effects of serum on in vitro susceptibility testing of echinocandins

Odabasi Z., Paetznick V., Rex J. H., Ostrosky-Zeichner L.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.51, no.11, pp.4214-4216, 2007 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 11
  • Publication Date: 2007
  • Doi Number: 10.1128/aac.01589-06
  • Journal Name: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4214-4216
  • Marmara University Affiliated: Yes

Abstract

The effects of protein binding on the activities of caspofungin, anidulafungin, and micafungin were evaluated against Candida and Aspergillus species. Adding human serum sharply increased the MICs of micafungin and anidulafungin and modestly affected the MIC of caspofungin. The increase in MICs does not appear consistent with the rate of protein binding for the three compounds.