Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

Imeryuz N., Tahan V., Sonsuz A., Eren F., Uraz S., Yuksel M., ...Daha Fazla

JOURNAL OF HEPATOLOGY, cilt.47, sa.6, ss.851-859, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jhep.2007.06.018
  • Dergi Adı: JOURNAL OF HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.851-859
  • Anahtar Kelimeler: liver fibrosis, methionine and choline deficient diet, necroinflammation, reactive oxygen species, nonalcoholic steatohepatitis, MITOCHONDRIAL PERMEABILITY TRANSITION, NONALCOHOLIC STEATOHEPATITIS, HEPATIC IRON, FATTY LIVER, HEPATOCYTE APOPTOSIS, LIPID-PEROXIDATION, PROTEIN ADDUCTS, IN-VIVO, MODEL, FIBROSIS
  • Marmara Üniversitesi Adresli: Evet

Özet

Background/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).