Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death


Imeryuz N., Tahan V., Sonsuz A., Eren F. , Uraz S., Yuksel M. , et al.

JOURNAL OF HEPATOLOGY, cilt.47, ss.851-859, 2007 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 47 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jhep.2007.06.018
  • Dergi Adı: JOURNAL OF HEPATOLOGY
  • Sayfa Sayısı: ss.851-859

Özet

Background/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).