Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo

Taylor H., Schmiedt J. T. , Carcak N., ONAT F. , Di Giovanni G., Lambert R. C. , ...Daha Fazla

JOURNAL OF NEUROSCIENCE METHODS, cilt.235, ss.83-91, 2014 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 235
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jneumeth.2014.06.031
  • Sayfa Sayıları: ss.83-91


Background: The advent of optogenetics has given neuroscientists the opportunity to excite or inhibit neuronal population activity with high temporal resolution and cellular selectivity. Thus, when combined with recordings of neuronal ensemble activity in freely moving animals optogenetics can provide an unprecedented snapshot of the contribution of neuronal assemblies to (patho)physiological conditions in vivo. Still, the combination of optogenetic and silicone probe (or tetrode) recordings does not allow investigation of the role played by voltage- and transmitter-gated channels of the opsin-transfected neurons and/or other adjacent neurons in controlling neuronal activity.