Assessment of Transmitted HIV-1 Drug Resistance Mutations Using Ultra-Deep Pyrosequencing in a Turkish Cohort

SİLİ U., Aksu B., Tekin A., Hasdemir U., Soyletir G., KORTEN V.

CURRENT HIV RESEARCH, cilt.16, sa.3, ss.216-221, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570162x16666180910130112
  • Dergi Adı: CURRENT HIV RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.216-221
  • Anahtar Kelimeler: Antiretroviral drug resistance, human immunodeficiency virus, minority variants, rilpivirine resistance, transmitted drug resistance, ultra-deep pyrosequencing, IMMUNODEFICIENCY-VIRUS TYPE-1, ANTIRETROVIRAL THERAPY, NAIVE PATIENTS, VARIANTS, RECOMMENDATIONS, SURVEILLANCE, IMPACT
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Antiretroviral treatment (ART) reduces morbidity and mortality caused by human immunodeficiency virus (HIV) infection; however, the emergence of drug-resistant strains poses an important obstacle to treatment success. Using conventional sequencing methods to determine antiretroviral resistance, mutations present in >= 20% of quasispecies can be identified, but drug-resistant minority variants can lead to virologic failure.