Assessment of Transmitted HIV-1 Drug Resistance Mutations Using Ultra-Deep Pyrosequencing in a Turkish Cohort


SİLİ U. , Aksu B. , Tekin A., Hasdemir U., Soyletir G., KORTEN V.

CURRENT HIV RESEARCH, cilt.16, ss.216-221, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Antiretroviral treatment (ART) reduces morbidity and mortality caused by human immunodeficiency virus (HIV) infection; however, the emergence of drug-resistant strains poses an important obstacle to treatment success. Using conventional sequencing methods to determine antiretroviral resistance, mutations present in >= 20% of quasispecies can be identified, but drug-resistant minority variants can lead to virologic failure.