Chitosan-co-Hyaluronic acid porous cryogels and their application in tissue engineering

Kutlusoy T., OKTAY B., KAYAMAN APOHAN N., Silleymanoglu M., Kuruca S. E.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, cilt.103, ss.366-378, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ijbiomac.2017.05.067
  • Dergi Adı: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.366-378
  • Anahtar Kelimeler: Chitosan, Cryogel, Hyaluronic acid, MTT, Tissue engineering, SCAFFOLD DESIGN, CROSS-LINKING, HYDROGELS, BIOMATERIALS, CHITIN, FILMS
  • Marmara Üniversitesi Adresli: Evet

Özet

In this work, the usability of chitosan-co-hyaluronic acid cryogels as a tissue-engineering scaffold was investigated. Chitosan-co-hyaluronic acid cryogels were synthesized at subzero temperature. Cryogels which were composed of various compositions of chitosan and hyaluronic acid (0, 10, 20, 30 and 50 wt% hyaluronic acid) was prepared. Morphological studies showed that the macroporous cryogels have been developed with 90-95% porosity. Particularly, the mechanical and biomaterial property of pure chitosan was improved by making copolymer with hyaluronic acid in different concentration. The MIT cell viability results demonstrated that the cryogels have no significant cytotoxicity effect on 3T3 fibroblast and SAOS-2 cells. (C) 2017 Elsevier B.V. All rights reserved.