Akademik Veri Yönetim Sistemi
Literatür Eczacılık Bilimleri Dergisi, cilt.12, sa.1, ss.1-7, 2023 (Hakemli Dergi)
Objective: Proton pump inhibitors (PPIs) are the most prescribed gastrointestinal system medications and are often pre- scribed together with other medications. This may lead to drug inter- actions. In our study, it was aimed to determine the possible interactions of PPIs. Material and Methods: This retrospective study was conducted between January 1, 2021 and March 31, 2021. A pre- scription review was conducted in a community pharmacy inİstanbul and potential drug interactions were evaluated using the Medscape and Lexicomp databases. Results: A total of 114 prescriptions were reviewed. The mean age of the patients was 55.1±14.8 years, and the mean duration of PPIs use was 5 months. It was determined that the one who prescribed PPIs the most was the family physician and it was prescribed most frequently with the indication of gastroesophageal reflux disease. The total number of interactions in the prescriptions was determined as 248 in the Medscape database and 295 in the Lex- icomp database (p<0.05). Pantoprazole was found to be the most in- teracting PPIs in both databases. Levothyroxine was found to be the drug that interacted most with PPIs in both databases. Age and dura- tion of PPIs use were found to be positively significantly correlated (p<0.05). Conclusion: In our study, the number of potential drug in- teractions in prescriptions containing PPIs was found to be high. We think that the possible interactions and duration of use of drugs used due to comorbid diseases should be considered in prescriptions con- taining PPIs.