Immunosuppressive therapy in lupus nephritis - The Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide


Houssiau F., Vasconcelos C., D'Cruz D., Sebastiani G., Garrido E., Danieli M., ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.46, sa.8, ss.2121-2131, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Konu: 8
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1002/art.10461
  • Dergi Adı: ARTHRITIS AND RHEUMATISM
  • Sayfa Sayıları: ss.2121-2131

Özet

Objective. Glomerulonephritis is a severe manifestation of systemic lupus erythematosus (SLE) that is usually treated with an extended course of intravenous (IV) cyclophosphamide (CYC). Given the side effects of this regimen, we evaluated the efficacy and the toxicity of a course of low-dose IV CYC prescribed as a remission-inducing treatment, followed by azathioprine (AZA) as a remission-maintaining treatment.