Efficacy of N-acetylcysteine in preventing amphotericin B induced acute kidney injury


ERTÜRK ŞENGEL B. , Tukenmez Tigen E., TOPTAŞ T. , ATAGÜNDÜZ I. , TUĞLULAR A. T. , Ergonul M. O. , ...More

MARMARA MEDICAL JOURNAL, vol.29, no.2, pp.73-78, 2016 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.5472/mmjoa.2902.02
  • Title of Journal : MARMARA MEDICAL JOURNAL
  • Page Numbers: pp.73-78

Abstract

Objectives: Previously, in an animal study we showed that N-acetylcysteine (NAC) could decrease deoxycholate amphotericin B (DAmB) induced renal tubular apoptosis. In this clinical study, we aimed to evaluate the efficacy of NAC in preventing acute kidney injury (AKI) in febrile neutropenic patients with invasive pulmonary aspergillosis treated with DAmB.