Prognostic Significance of Tumor Budding in Ampullary Carcinomas
International Journal of Surgical Pathology, cilt.33, sa.5, ss.1135-1141, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 5
- Basım Tarihi: 2025
- Doi Numarası: 10.1177/10668969241308204
- Dergi Adı: International Journal of Surgical Pathology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1135-1141
- Anahtar Kelimeler: adenocarcinoma, ampulla of Vater, carcinoma, pancreas, tumor budding
- Marmara Üniversitesi Adresli: Evet
Özet
Objective. The presence of high tumor budding in colorectal carcinomas is a significant pathological feature indicative of a high potential for lymph node metastasis. Our aim was to investigate the prognostic impact of tumor budding in ampullary carcinomas. Materials and methods. We conducted a cohort of 101 consecutive ampullary carcinoma resections to evaluate tumor budding, macroscopic and microscopic subtypes, lymphatic/vascular/perineural invasions, and other histopathological parameters. Results. High tumor budding was observed in 49 (49%) of the tumors, and multivariate survival analysis evaluating the overall survival of these patients found tumor budding to be an independent poor prognostic indicator (p = 0.013). Conclusion. Tumor budding should be reported in ampullary carcinomas as it serves as an independent predictor of a poor outcome.