Prognostic Significance of Tumor Budding in Ampullary Carcinomas

AKAR K. E., Bagci P.

International Journal of Surgical Pathology, vol.33, no.5, pp.1135-1141, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 5
  • Publication Date: 2025
  • Doi Number: 10.1177/10668969241308204
  • Journal Name: International Journal of Surgical Pathology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.1135-1141
  • Keywords: adenocarcinoma, ampulla of Vater, carcinoma, pancreas, tumor budding
  • Marmara University Affiliated: Yes

Abstract

Objective. The presence of high tumor budding in colorectal carcinomas is a significant pathological feature indicative of a high potential for lymph node metastasis. Our aim was to investigate the prognostic impact of tumor budding in ampullary carcinomas. Materials and methods. We conducted a cohort of 101 consecutive ampullary carcinoma resections to evaluate tumor budding, macroscopic and microscopic subtypes, lymphatic/vascular/perineural invasions, and other histopathological parameters. Results. High tumor budding was observed in 49 (49%) of the tumors, and multivariate survival analysis evaluating the overall survival of these patients found tumor budding to be an independent poor prognostic indicator (p = 0.013). Conclusion. Tumor budding should be reported in ampullary carcinomas as it serves as an independent predictor of a poor outcome.