Outcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors

ÖZEN A. O. , Baris S. , Karakoc-Aydiner E. , Ozdemir C., Bahceciler N., Barlan I.

CLINICAL IMMUNOLOGY, vol.137, no.3, pp.374-383, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1016/j.clim.2010.08.010
  • Title of Journal : CLINICAL IMMUNOLOGY
  • Page Numbers: pp.374-383
  • Keywords: THI, CVID, Unclassified Hypogammaglobulinemia, Predictors, Outcome, Allergy, B cell, Antibody response, Immunoglobulin level, IgM, SELECTIVE IGA DEFICIENCY, TRANSIENT HYPOGAMMAGLOBULINEMIA, PRIMARY IMMUNODEFICIENCIES, EARLY-CHILDHOOD, INFANCY, TURKEY


We evaluated 131 children (M=88, F=43) with hypogammaglobulinemia Data was analyzed mainly for delineating predictor factors for outcome The distance from the lower limit of normal (-2SD) for any single measurement of immunoglobulins (Ig) was calculated and transformed into Ig scores Mean age and duration of follow up were 5 06 +/- 4 05 and 3 7 +/- 3 03 years, respectively The diagnoses were 22 CVID, 16 IgA deficiency, 33 transient hypogammaglobulinemia of childhood (THC), 3 selective IgM deficiency and 57 unclassified hypogammaglobulinemia (UCH) Low IgA scores (<-0 124) at presentation were indicative of subsequent development of IgA deficiency or CVID, whereas low IgM score (<-0 038) pointed towards more severe and persistent phenotypes Combination of low IgM score between 2 and 5 years, impaired antibody response and low B cell counts enabled us to predict persistence of hypogammaglobulinemia beyond 5 years (specificity = 90 5% and PPV = 94 9%) and chronic lung disease (sensitivity =90 4% and specificity = 68 3%) The set of criteria including low IgM scores, impaired antibody response and low B cell counts provided a high predictive value in detecting those with persistent hypogammaglobulinemia (C) 2010 Elsevier Inc All rights reserved