The Neurochemical Effects of Prazosin Treatment on Fear Circuitry in a Rat Traumatic Stress Model

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Ketenci S., Acet N. G., Sarıdoğan G. E., Aydın B., Cabadak H., Gören M. Z.

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, cilt.18, ss.219-230, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18
  • Basım Tarihi: 2020
  • Doi Numarası: 10.9758/cpn.2020.18.2.219
  • Dergi Adı: CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Psycinfo
  • Sayfa Sayıları: ss.219-230
  • Anahtar Kelimeler: Noradrenalline, Rostral pons, Cholinergic, Gamma-aminobuytyric acid, Glutamic acid, Glycine, LOCUS-CERULEUS NEURONS, ANIMAL-MODEL, ALPHA-1-ADRENERGIC RECEPTORS, CARDIOVASCULAR-RESPONSES, AMYGDALA, EXTINCTION, ANXIETY, CONSOLIDATION, PROPRANOLOL, ANTAGONISTS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: The timing of administration of pharmacologic agents is crucial in traumatic stress since they can either potentiate the original fear memory or may cause fear extinction depending on the phase of fear conditioning. Brain noradrenergic system has a role in fear conditioning. Data regarding the role of prazosin in traumatic stress are controversial.