Akademik Veri Yönetim Sistemi
25th international conference of the european society for precision engineering and nanotechnology, Zaragoza, İspanya, 9 - 13 Haziran 2025, ss.138-139, (Tam Metin Bildiri)
One innovative way to incorporate biological components with materials used in damaged tissue regeneration is through tissue engineering. The main goal of neural tissue engineering is to find ways to reduce fibrosis and inflammation after foreign materials that can act as a scaffold for cell development are implanted. With great potential, neural tissue engineering offers a compelling technological advance in restoring brain function. On the other hand, creating implantable scaffolds for brain culture that meet all the requirements is an incredible challenge for material science. These materials require numerous desirable properties, such as support for cellular survival, proliferation, and neuronal migration as well as the reduction of inflammatory reactions. In addition, they ought to support electrical communication between cells, exhibit brain-like mechanical characteristics, mimic the complex structure of the extracellular matrix, and ideally permit drug release under control. In this study, the initial composition and geometry of 3D-printed neural scaffolds were produced by extrusion-based 3D printing technology. These 3D-printed scaffolds were based on polycaprolactone (PCL). The graphene oxide (GO) and polyaniline (PANI) were added separately to provide electrical conductivity. In addition, the study aims to observe the characteristic difference between 0.1 wt.% PANI and GO-added 25% PCL scaffolds. The morphological analysis was performed with a scanning electron microscope (SEM) and chemical characterization was carried out with fourier-transformed infrared spectroscopy (FTIR). SEM images showed the successful printing of the scaffolds with pores. The biocompatibility test was performed with human neuroblastoma cells (SH-SY5Y) and the results demonstrated that all scaffolds had high biocompatibility.