Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips

Unal M., Palavan-Unsal N., Tufekci M. A.

ACTA BIOLOGICA HUNGARICA, cilt.59, sa.1, ss.93-102, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Konu: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1556/abiol.59.2008.1.8
  • Sayfa Sayıları: ss.93-102


The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine ( Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, alpha-difluoromethylornithine ( DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) ( MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity.